 | |||||||||
|
|||||||||
|
Digital Microfluidic Vitrification of Embryos
Cryopreservation is a key technology in biology and clinical practice. This video shows a digital microfluidic device that automates sample preparation for mammalian embryo vitrification. Individual micro droplets manipulated on the microfluidic device were used as micro-vessels to transport a single mouse embryo through a complete vitrification procedure. Advantages of this approach, compared to manual operation and channel-based microfluidic vitrification, include automated operation, cryoprotectant concentration gradient generation, and feasibility of loading and retrieval of embryos. For details, refer to [J112] on the Publications
page.
Decreased Deformability of Lymphocytes
in Leukemia
This video shows
the measurement of stiffness/deformability changes of lymphocytes in chronic
lymphocytic leukemia (CLL) patients, demonstrating that at the single cell
level, leukemic metastasis progresses are accompanied by biophysical property
alterations. A microfluidic device was utilized to electrically measure cell
volume and transit time of single lymphocytes from healthy and CLL patients.
The results from testing thousands of cells reveal that lymphocytes from CLL
patients have higher stiffness (i.e., lower deformability). For details, refer
to [J115] on the Publications
page.
|
|
||||||||
